Residents in St Albans and Harpenden are being asked to donate their unwanted clothes, shoes and toys as part of the Great British Baga-thon.
This year people can take on the bag-filling challenge to raise money for the British Heart Foundation, as part of vital funds for life-saving research into heart disease.
BHF aim to raise 1 million bags of unwanted things for vital funds for life-saving research into heart disease.
Throughout the month of September, local shops will aim to raise almost 2,000 bags full of unwanted things.
Suzanne Halsey, area manager for BHF shops, said: "The launch of the Great British Bag-athon is only a few weeks away and we’d like everyone in the Hertfordshire area to set aside some time to clear out their wardrobe and join in the UKs biggest bag filling event.
"Every bag that you fill is a bag full of life saving research.
"Your clothes, shoes, bags, books, DVDs, homewares and toys will help Hertfordshire BHF shops fight for every heart beat."
Residents can clear their wardrobes of any unwanted clothes, shoes, toys, books, CDs, DVDs and drop them at their local BHF shops. To register online visit bhf.org.uk/bagathon.